A Point Mutation in Sec61 1 Leads to Diabetes and Hepatosteatosis in Mice
نویسندگان
چکیده
منابع مشابه
A Point Mutation in Sec61α1 Leads to Diabetes and Hepatosteatosis in Mice
OBJECTIVE Type 2 diabetes is caused by both environmental and genetic factors. To better understand the genetic factors we used forward genetics to discover genes that have not previously been implicated in the development of hyperglycemia or diabetes. RESEARCH DESIGN AND METHODS Offspring of ethylnitrosurea-mutagenized C57BL/6 mice were bred to homozygosity, maintained on high-fat diet, and ...
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ژورنال
عنوان ژورنال: Diabetes
سال: 2009
ISSN: 0012-1797,1939-327X
DOI: 10.2337/db08-1362